Breaking bad: R-loops and genome integrity

Highlights • R-loops are dynamic structures that regulate diverse cellular processes. • R-loops threaten genomic and epigenomic stability. • R-loops are associated with cancer and neurodegenerative diseases.

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Bibliographic Details
Published in:Trends in cell biology 2015-09, Vol.25 (9), p.514-522
Main Authors: Sollier, Julie, Cimprich, Karlene A
Format: Article
Language:English
Subjects:
Animals
Chromatin - physiology
Chromatin - ultrastructure
DNA Damage
DNA Repair
DNA, Single-Stranded - physiology
Epigenesis, Genetic
epigenomic stability
gene expression
Genomic Instability
Humans
Pathology
R-loop
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Description
Summary:Highlights • R-loops are dynamic structures that regulate diverse cellular processes. • R-loops threaten genomic and epigenomic stability. • R-loops are associated with cancer and neurodegenerative diseases.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2015.05.003