Fluoroquinolones or macrolides alone versus combined with β-lactams for adults with community-acquired pneumonia: Systematic review and meta-analysis

Highlights • Meta-analysis comparing quinolone or macrolide monotherapy with combination therapy with β-lactams. • Mortality was similar in both groups of mainly hospitalised patients. • Clinical failure and toxicity were lower in patients receiving fluoroquinolones. • The ecological impact of choos...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2015-09, Vol.46 (3), p.242-248
Main Authors: Raz-Pasteur, Ayelet, Shasha, David, Paul, Mical
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
beta-Lactams - adverse effects
beta-Lactams - therapeutic use
Community-Acquired Infections - drug therapy
Community-acquired pneumonia
Drug Therapy, Combination - methods
Drug-Related Side Effects and Adverse Reactions
Fluoroquinolones - adverse effects
Fluoroquinolones - therapeutic use
Humans
Infectious Disease
Macrolides
Macrolides - adverse effects
Macrolides - therapeutic use
Meta-analysis
Pneumonia, Bacterial - drug therapy
Quinolones
Randomized Controlled Trials as Topic
Review
Survival Analysis
Systematic
Treatment Failure
Treatment Outcome
Withholding Treatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Meta-analysis comparing quinolone or macrolide monotherapy with combination therapy with β-lactams. • Mortality was similar in both groups of mainly hospitalised patients. • Clinical failure and toxicity were lower in patients receiving fluoroquinolones. • The ecological impact of choosing a quinolone as primary treatment for community-acquired pneumonia is unknown.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.04.010