Randomized controlled trial of insulin detemir versus NPH for the treatment of pregnant women with diabetes

Objective We sought to determine if insulin detemir (IDet) is noninferior to insulin neutral protamine Hagedorn (NPH) for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) in pregnancy. Study Design We conducted a randomized, controlled noninferiority trial of...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2015-09, Vol.213 (3), p.426.e1-426.e7
Main Authors: Herrera, Kimberly M., MD, Rosenn, Barak M., MD, Foroutan, Janelle, MD, Bimson, Brianne E., MD, Al Ibraheemi, Zainab, MD, Moshier, Erin L., MS, Brustman, Lois E., MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Diabetes Mellitus, Type 2 - drug therapy
Diabetes, Gestational - drug therapy
Drug Administration Schedule
Female
gestational diabetes
Humans
Hypoglycemic Agents - therapeutic use
Insulin Detemir
insulin neutral protamine Hagedorn
Insulin, Isophane - therapeutic use
Insulin, Long-Acting - therapeutic use
Intention to Treat Analysis
Obstetrics and Gynecology
Pregnancy
Pregnancy in Diabetics - drug therapy
Treatment Outcome
type 2 diabetes
Young Adult
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Summary:Objective We sought to determine if insulin detemir (IDet) is noninferior to insulin neutral protamine Hagedorn (NPH) for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) in pregnancy. Study Design We conducted a randomized, controlled noninferiority trial of women with GDM and T2DM who entered our Diabetes in Pregnancy Program from March 2013 through October 2014. Exclusion criteria were type 1 diabetes, age
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2015.06.010