Pleiotropic effects of statins in hypercholesterolaemia: a prospective observational study using a lipoproteomic based approach

Abstract Background The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions du...

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Bibliographic Details
Published in:The Lancet (British edition) 2015-02, Vol.385, p.S21-S21
Main Authors: Bhandari, Sanjay, Dr, Gupta, Pankaj, MBBS, Quinn, Paulene, MPhil, Sandhu, Jatinderpal, MPhil, Hakimi, Amirmansoor, PhD, Jones, Donald, PhD, Ng, Leong, Prof
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Internal Medicine
Liquid chromatography
Mass spectrometry
Observational studies
Prevention
Proteins
Redox reactions
Statins
Stem cells
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Summary:Abstract Background The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. The aim of this study was to determine the effect of statin therapy on lipoproteins and their protein cargo by use of an unbiased bottom-up proteomics approach in people with hypercholesterolaemia. Methods 11 people fulfilling the inclusion criteria were recruited into this UK-based single centre prospective observational study. They were started on statins for primary prevention. Blood was withdrawn at baseline and after a minimum of 2 months of statin therapy. Plasma was co-incubated with a lipoaffinity resin. Isolated proteins were digested and analysed with label-free two-dimensional liquid chromatography coupled to electrospray high-definition ion mobility tandem mass spectrometry. Findings 218 proteins were identified with Progenesis QI software, with 33 proteins demonstrating significant differential expression between the pre-statin and the on-statin samples (each p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(15)60336-1