Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics: A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Trial

Erectile dysfunction is a man’s persistent or recurrent inability to achieve and maintain erection for a satisfactory sexual relationship. As diabetes is a major risk factor for erectile dysfunction, the prevalence of erectile dysfunction among diabetic men has been reported as 35% to 90%. This rand...

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Bibliographic Details
Published in:Journal of evidence-based complementary & alternative medicine 2015-10, Vol.20 (4), p.283-286
Main Authors: Mohammadzadeh-Moghadam, Hossein, Nazari, Seyed Mohammad, Shamsa, Ali, Kamalinejad, Mohammad, Esmaeeli, Habibollah, Asadpour, Amir Abbas, Khajavi, Abdoljavad
Format: Article
Language:English
Subjects:
Adult
Aged
Crocus - chemistry
Diabetes Complications - drug therapy
Diabetes Complications - physiopathology
Double-Blind Method
Erectile Dysfunction - drug therapy
Erectile Dysfunction - etiology
Erectile Dysfunction - physiopathology
Gels - administration & dosage
Humans
Male
Middle Aged
Phytotherapy
Plant Extracts - administration & dosage
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Summary:Erectile dysfunction is a man’s persistent or recurrent inability to achieve and maintain erection for a satisfactory sexual relationship. As diabetes is a major risk factor for erectile dysfunction, the prevalence of erectile dysfunction among diabetic men has been reported as 35% to 90%. This randomized, parallel-group, double-blind, placebo-controlled trial investigated the effects of a topical saffron (Crocus sativus L) gel on erectile dysfunction in diabetic men. Patients were randomly allocated to 2 equal groups (with 25 patients each). The intervention group was treated with topical saffron, and the control received a similar treatment with placebo. The 2 groups were assessed using the International Index of Erectile Function Questionnaire before the intervention and 1 month after the intervention. Compared to placebo, the prepared saffron gel could significantly improve erectile dysfunction in diabetic patients (P < .001). This preliminary evidence suggests that saffron can be considered as a treatment option for diabetic men with erectile dysfunction.
ISSN:2156-5872
2156-5899
DOI:10.1177/2156587215583756