Acinetobacter baumannii infections in a South African paediatric intensive care unit

To describe and compare characteristics and outcomes of patients colonized or infected with Acinetobacter baumannii (cases) to a control group. A retrospective case-controlled study of patients admitted to a South African paediatric intensive care unit (PICU) between January and December 2010. Acine...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2015-06, Vol.61 (3), p.182-187
Main Authors: Reddy, Deveshni, Morrow, Brenda M, Argent, Andrew C
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - diagnosis
Acinetobacter Infections - drug therapy
Acinetobacter Infections - mortality
Anti-Bacterial Agents - therapeutic use
Case-Control Studies
Child, Preschool
Cross Infection - diagnosis
Cross Infection - drug therapy
Cross Infection - mortality
Female
Humans
Infant
Infant, Newborn
Intensive Care Units, Pediatric - statistics & numerical data
Length of Stay
Logistic Models
Male
Multivariate Analysis
Nutritional Status
Respiration, Artificial
Retrospective Studies
Risk Factors
South Africa - epidemiology
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Summary:To describe and compare characteristics and outcomes of patients colonized or infected with Acinetobacter baumannii (cases) to a control group. A retrospective case-controlled study of patients admitted to a South African paediatric intensive care unit (PICU) between January and December 2010. Acinetobacter baumannii was isolated in 194 patients. Mortality was similar between cases (9.3%) and controls (9.8%). Median duration of PICU stay and mechanical ventilation in cases vs. controls was 10 vs. 2 (p < 0.0001) and 9 vs. 1 days (p < 0.0001), respectively. Admission diagnosis of traumatic brain injury [adjusted odds ratio (OR): 5.6, 95% CI: 1.2-27.0; p = 0.03] and duration of mechanical ventilation (adjusted OR: 1.4, 95% CI: 1.3-1.5; p < 0.0001) were independently associated with A. baumannii aquisition. Acinetobacter baumannii acquisition was common and associated with increased morbidity, but not increased mortality.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmv017