Implementation of HPV‐testing for cervical cancer screening in programmatic contexts: The Jujuy demonstration project in Argentina

• Published in: International journal of cancer 2015-10, Vol.137 (7), p.1709-1718
• Main Authors: Arrossi, Silvina, Thouyaret, Laura, Laudi, Rosa, Marín, Oscar, Ramírez, Josefina, Paolino, Melisa, Herrero, Rolando, Campanera, Alicia
• Format: Article
• Language: English
• Subjects: Adult; Aged; Argentina; Argentina - epidemiology; Cancer; Cellular biology; Cervical cancer; cervical cancer prevention; Female; HPV test; Human papillomavirus; Humans; Mass Screening - methods; Mass Screening - organization & administration; Medical research; Medical screening; Middle Aged; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; screening; Uterine Cervical Dysplasia - diagnosis; Uterine Cervical Dysplasia - epidemiology; Uterine Cervical Dysplasia - virology; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - prevention & control; Uterine Cervical Neoplasms - virology; Womens health; Young Adult
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.29530

The aim of this article is to present results of programmatic introduction of HPV testing with cytologic triage among women 30 years and older in the province of Jujuy, Argentina, including description of the planning phase and results of program performance during the first year. We describe the project implementation process, and calculate key performance indicators using SITAM, the national screening information system. We also compare disease detection rates of HPV testing in 2012 with cytology as performed during the previous year. HPV testing with cytology triage was introduced through a consensus‐building process. Key activities included establishment of algorithms and guidelines, creating the HPV laboratory, training of health professionals, information campaigns for women and designing the referral network. By the end of 2012, 100% (n = 270) of public health care centers were offering HPV testing and 22,834 women had been HPV tested, 98.5% (n = 22,515) were 30+. HPV positivity among women over 30 was 12.7%, 807 women were HPV+ and had abnormal cytology, and 281 CIN2+ were identified. CIN2+ detection rates was 1.25 in 2012 and 0.62 in 2011 when the program was cytology based (p = 0.0002). This project showed that effective introduction of HPV testing in programmatic contexts of low‐middle income settings is feasible and detects more disease than cytology. What's new? DNA testing for human papillomavirus (HPV) is rapidly becoming the preferred test for cervical cancer screening programs. But few studies have evaluated implementation strategies or program performance. Here, both implementation and performance are described for a recently introduced program for routine HPV‐testing in the province of Jujuy, Argentina. The report details the year‐long planning and implementation phase, during which fundamental components, including guidelines and outreach strategies, were developed. Analyses show that the program's main screening goals were fulfilled in its first year. The program's success inspired the rollout of HPV‐testing to other Argentinian provinces.