The type and composition of alginate and hyaluronic-based hydrogels influence the viability of stem cells of the apical papilla

Highlights • We evaluated the impact of alginate- and hyaluronic acid-based hydrogel on SCAP viability. • Hydrogel composition influenced in vitro SCAP viability and metabolic activity. • SCAPs survived in vivo for 1 week. • The appropriate combination of surface and mechanical characteristics dicta...

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Bibliographic Details
Published in:Dental materials 2014-12, Vol.30 (12), p.e349-e361
Main Authors: Lambricht, Laure, De Berdt, Pauline, Vanacker, Julie, Leprince, Julian, Diogenes, Anibal, Goldansaz, Hadi, Bouzin, Caroline, Préat, Véronique, Dupont-Gillain, Christine, Rieux, Anne des
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alginate
Alginates
Alginates - chemistry
Animals
Apoptosis - physiology
Biocompatible Materials - chemistry
Biomedical materials
Cell Line
Cell Survival - physiology
Collagen - chemistry
Dental Papilla - cytology
Dental pulp
Dentistry
Drug Combinations
Elastic Modulus
Female
Heterografts - transplantation
Humans
Hyaluronic acid
Hyaluronic Acid - chemistry
Hydrogel
Hydrogels
Hydrogels - chemistry
In vitro testing
In vivo testing
In vivo tests
Laminin - chemistry
Mice
Microscopy, Electron, Scanning
Photoelectron Spectroscopy
Porosity
Proteoglycans - chemistry
Regenerative endodontics
Rheology
SCAP
Stem Cell Transplantation - methods
Stem cells
Stem Cells - physiology
Stress, Mechanical
Surface Properties
Surgical implants
Tissue engineering
Tissue Scaffolds - chemistry
Viability
Viscosity
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Summary:Highlights • We evaluated the impact of alginate- and hyaluronic acid-based hydrogel on SCAP viability. • Hydrogel composition influenced in vitro SCAP viability and metabolic activity. • SCAPs survived in vivo for 1 week. • The appropriate combination of surface and mechanical characteristics dictated SCAP fate.
ISSN:0109-5641
1879-0097
DOI:10.1016/j.dental.2014.08.369