Gastroprotective potential against indomethacin and safety assessment of the homology of medicine and food formula cuttlebone complex

Cuttlebone complex (CBC), a homology of medicine and food formula, is comprised of five herbal medicines ( Endoconcha Sepiae , Radix Paeoniae Rubra , fresh ginger, Fructus Amomi , and Radix Glycyrrhizae ) and two food ingredients ( Zingiber zerumbet and chitosan). Herein, the gastroprotective potent...

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Bibliographic Details
Published in:Food & function 2015-08, Vol.6 (8), p.283-2812
Main Authors: Chien, Mei-Yin, Lin, Yi-Ting, Peng, Fu-Chuo, Lee, Huei-Jane, Chang, Jin-Ming, Yang, Chih-Min, Chen, Chao-Hsiang
Format: Article
Language:English
Subjects:
Animals
CHO Cells
Cricetinae
Cricetulus
Gastric Mucosa - drug effects
Humans
Indomethacin - adverse effects
Male
Mice
Mice, Inbred ICR
Mutagenicity Tests
Plant Extracts - administration & dosage
Plant Extracts - adverse effects
Plants, Medicinal - adverse effects
Plants, Medicinal - chemistry
Protective Agents - administration & dosage
Protective Agents - adverse effects
Rats
Rats, Sprague-Dawley
Salmonella
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Zingiber
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Summary:Cuttlebone complex (CBC), a homology of medicine and food formula, is comprised of five herbal medicines ( Endoconcha Sepiae , Radix Paeoniae Rubra , fresh ginger, Fructus Amomi , and Radix Glycyrrhizae ) and two food ingredients ( Zingiber zerumbet and chitosan). Herein, the gastroprotective potential against indomethacin and a safety assessment of CBC were investigated. In a gastroprotective model, CBC effectively decreased the indomethacin-increased gastric ulcerous lesions, and increased the indomethacin-decreased prostaglandin E2 levels in the gastric mucosa. In genotoxicity tests, CBC treatment did not increase the numbers of revertant colonies in five Salmonella typhimurium strains and chromosome aberrations in Chinese hamster ovary CHO-K1 cells, with or without S9 metabolic activation. The oral supplementation of CBC did not increase micronucleus formation in the peripheral blood of mice. In a subacute toxicity study, the body weight and blood biochemical parameters observed in CBC-treated rats were normal. In conclusion, CBC was considered as a non-toxic formula and could be used to remedy indomethacin-induced gastric damage. In this work, the gastroprotective potential against indomethacin and a safety assessment of cuttlebone complex (CBC) were investigated.
ISSN:2042-6496
2042-650X
DOI:10.1039/c5fo00638d