Cell proliferation in the cochlear nucleus following acoustic trauma in rat

Highlights • We investigated cell proliferation in the CN following acoustic trauma in rats. • Cell proliferation increased in the CN in a time-dependent fashion. • The new cells co-labeled for doublecortin (DCX), a marker of immature neurons • The new cells did not co-label for CD-11b, a marker of...

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Bibliographic Details
Published in:Neuroscience 2015-09, Vol.303, p.524-534
Main Authors: Zheng, Y, Smithies, H, Aitken, P, Gliddon, C, Stiles, L, Darlington, C.L, Smith, P.F
Format: Article
Language:English
Subjects:
Acoustic Stimulation - adverse effects
acoustic trauma
Analysis of Variance
Animals
auditory system
BrdU
Bromodeoxyuridine - metabolism
CD11b Antigen - metabolism
cell proliferation
Cell Proliferation - physiology
cochlear nucleus
Cochlear Nucleus - pathology
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
Hearing Loss, Noise-Induced - pathology
Hearing Loss, Noise-Induced - physiopathology
Ki-67 Antigen - metabolism
Male
Microtubule-Associated Proteins - metabolism
neurogenesis
Neurogenesis - physiology
Neurology
Neuropeptides - metabolism
Rats
Rats, Wistar
Time Factors
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Summary:Highlights • We investigated cell proliferation in the CN following acoustic trauma in rats. • Cell proliferation increased in the CN in a time-dependent fashion. • The new cells co-labeled for doublecortin (DCX), a marker of immature neurons • The new cells did not co-label for CD-11b, a marker of microglia. • However, there was no difference in DCX expression between sham and exposed animals.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.033