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Cell proliferation in the cochlear nucleus following acoustic trauma in rat
Highlights • We investigated cell proliferation in the CN following acoustic trauma in rats. • Cell proliferation increased in the CN in a time-dependent fashion. • The new cells co-labeled for doublecortin (DCX), a marker of immature neurons • The new cells did not co-label for CD-11b, a marker of...
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| Published in: | Neuroscience 2015-09, Vol.303, p.524-534 |
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| Main Authors: | , , , , , , |
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| container_end_page | 534 |
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| container_start_page | 524 |
| container_title | Neuroscience |
| container_volume | 303 |
| creator | Zheng, Y Smithies, H Aitken, P Gliddon, C Stiles, L Darlington, C.L Smith, P.F |
| description | Highlights • We investigated cell proliferation in the CN following acoustic trauma in rats. • Cell proliferation increased in the CN in a time-dependent fashion. • The new cells co-labeled for doublecortin (DCX), a marker of immature neurons • The new cells did not co-label for CD-11b, a marker of microglia. • However, there was no difference in DCX expression between sham and exposed animals. |
| doi_str_mv | 10.1016/j.neuroscience.2015.07.033 |
| format | article |
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Smithies, H ; Aitken, P ; Gliddon, C ; Stiles, L ; Darlington, C.L ; Smith, P.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-9619b4396db98e1d5f65459d3a0177188c6accd4efa4b3e85f51266f2bf2cd163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustic Stimulation - adverse effects</topic><topic>acoustic trauma</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>auditory system</topic><topic>BrdU</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>CD11b Antigen - metabolism</topic><topic>cell proliferation</topic><topic>Cell Proliferation - physiology</topic><topic>cochlear nucleus</topic><topic>Cochlear Nucleus - pathology</topic><topic>Disease Models, Animal</topic><topic>Evoked Potentials, Auditory, Brain Stem</topic><topic>Hearing Loss, Noise-Induced - pathology</topic><topic>Hearing Loss, Noise-Induced - physiopathology</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>neurogenesis</topic><topic>Neurogenesis - physiology</topic><topic>Neurology</topic><topic>Neuropeptides - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Y</creatorcontrib><creatorcontrib>Smithies, H</creatorcontrib><creatorcontrib>Aitken, P</creatorcontrib><creatorcontrib>Gliddon, C</creatorcontrib><creatorcontrib>Stiles, L</creatorcontrib><creatorcontrib>Darlington, C.L</creatorcontrib><creatorcontrib>Smith, P.F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Y</au><au>Smithies, H</au><au>Aitken, P</au><au>Gliddon, C</au><au>Stiles, L</au><au>Darlington, C.L</au><au>Smith, P.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell proliferation in the cochlear nucleus following acoustic trauma in rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2015-09-10</date><risdate>2015</risdate><volume>303</volume><spage>524</spage><epage>534</epage><pages>524-534</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • We investigated cell proliferation in the CN following acoustic trauma in rats. • Cell proliferation increased in the CN in a time-dependent fashion. • The new cells co-labeled for doublecortin (DCX), a marker of immature neurons • The new cells did not co-label for CD-11b, a marker of microglia. • However, there was no difference in DCX expression between sham and exposed animals.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26192094</pmid><doi>10.1016/j.neuroscience.2015.07.033</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2015-09, Vol.303, p.524-534 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Acoustic Stimulation - adverse effects acoustic trauma Analysis of Variance Animals auditory system BrdU Bromodeoxyuridine - metabolism CD11b Antigen - metabolism cell proliferation Cell Proliferation - physiology cochlear nucleus Cochlear Nucleus - pathology Disease Models, Animal Evoked Potentials, Auditory, Brain Stem Hearing Loss, Noise-Induced - pathology Hearing Loss, Noise-Induced - physiopathology Ki-67 Antigen - metabolism Male Microtubule-Associated Proteins - metabolism neurogenesis Neurogenesis - physiology Neurology Neuropeptides - metabolism Rats Rats, Wistar Time Factors |
| title | Cell proliferation in the cochlear nucleus following acoustic trauma in rat |
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