Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway

Human gut microbiota is being increasingly recognized as a player in colorectal cancers (CRCs). Evidence suggests that Fusobacterium nucleatum (F. nucleatum) may contribute to disease progression and is associated with CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) in CR...

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Bibliographic Details
Published in:International journal of cancer 2015-09, Vol.137 (6), p.1258-1268
Main Authors: Ito, Miki, Kanno, Shinichi, Nosho, Katsuhiko, Sukawa, Yasutaka, Mitsuhashi, Kei, Kurihara, Hiroyoshi, Igarashi, Hisayoshi, Takahashi, Taiga, Tachibana, Mami, Takahashi, Hiroaki, Yoshii, Shinji, Takenouchi, Toshinao, Hasegawa, Tadashi, Okita, Kenji, Hirata, Koichi, Maruyama, Reo, Suzuki, Hiromu, Imai, Kohzoh, Yamamoto, Hiroyuki, Shinomura, Yasuhisa
Format: Article
Language:English
Subjects:
Aged
Bacteria
BRAF
Cancer
Carcinogenesis - genetics
Cecum - microbiology
Cecum - pathology
Colon - microbiology
Colon - pathology
colon polyp
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - microbiology
Colorectal Neoplasms - pathology
colorectum
CpG Islands - genetics
DNA Methylation - genetics
dysplasia
Female
Fusobacterium
Fusobacterium Infections - genetics
Fusobacterium Infections - microbiology
Fusobacterium Infections - pathology
Fusobacterium nucleatum
Fusobacterium nucleatum - isolation & purification
Humans
KRAS
Male
Medical research
Microbiology
microbiome
MicroRNAs - genetics
Microsatellite Instability
miR‐31
MLH1
serrated neoplasia pathway
Tumors
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Summary:Human gut microbiota is being increasingly recognized as a player in colorectal cancers (CRCs). Evidence suggests that Fusobacterium nucleatum (F. nucleatum) may contribute to disease progression and is associated with CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) in CRCs; however, to date, there are no reports about the relationship between F. nucleatum and molecular features in the early stage of colorectal tumorigenesis. Therefore, we investigated the presence of F. nucleatum in premalignant colorectal lesions. In total, 465 premalignant lesions (343 serrated lesions and 122 non‐serrated adenomas) and 511 CRCs were studied. We determined the presence of F. nucleatum and analyzed its association with molecular features including CIMP, MSI and microRNA‐31 status. F. nucleatum was detected in 24% of hyperplastic polyps, 35% of sessile serrated adenomas (SSAs), 30% of traditional serrated adenomas (TSAs) and 33% of non‐serrated adenomas. F. nucleatum was more frequently detected in CIMP‐high premalignant lesions than in CIMP‐low/zero lesions (p = 0.0023). In SSAs, F. nucleatum positivity increased gradually from sigmoid colon to cecum (p = 0.042). F. nucleatum positivity was significantly higher in CRCs (56%) than in premalignant lesions of any histological type (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.29488