Genetic variant near TERC influencing the risk of gliomas with older age at diagnosis in a Chinese population

A recent genome-wide association study has identified an association between rs1920116 near TERC and high-grade glioma in populations of European ancestry. In order to evaluate the effect of the SNP rs1920116 near TERC in the Chinese population, we examined associations of this candidate SNP with gl...

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Bibliographic Details
Published in:Journal of neuro-oncology 2015-08, Vol.124 (1), p.57-64
Main Authors: Wang, Dianhong, Hu, Enxi, Wu, Pei, Yuan, Wenjing, Xu, Shancai, Sun, Zhe, Shi, Huaizhang, Yuan, Jingtao, Li, Guozhong, Zhao, Shiguang
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group
Brain Neoplasms - diagnosis
Brain Neoplasms - genetics
Female
Glioma - diagnosis
Glioma - genetics
Humans
Laboratory Investigation
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Oncology
Polymorphism, Single Nucleotide
Risk Factors
RNA - genetics
Telomerase - genetics
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Summary:A recent genome-wide association study has identified an association between rs1920116 near TERC and high-grade glioma in populations of European ancestry. In order to evaluate the effect of the SNP rs1920116 near TERC in the Chinese population, we examined associations of this candidate SNP with glioma in a sample of 1970 Chinese Han individuals. SNP genotype data were available for 980 Chinese glioma patients and 990 healthy controls. Logistic regression analyses were performed to evaluate the association between rs1920116 and glioma risk adjusted for age, gender and stratified by tumor grade where appropriate. The allele G at TERC rs1920116 are risk factors for gliomas, and its association with glioma risk was consistent across tumor subgroups in the Chinese Han population (OR = 1.18–1.21). In order to assess variation in SNP effect size at different patient ages, glioma cases and controls were divided into 3 age strata, in years:
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-015-1819-9