Liver transplantation nearly normalizes brain spontaneous activity and cognitive function at 1 month: a resting-state functional MRI study

To investigate the short-term brain activity changes in cirrhotic patients with Liver transplantation (LT) using resting-state functional MRI (fMRI) with regional homogeneity (ReHo) method. Twenty-six cirrhotic patients as transplant candidates and 26 healthy controls were included in this study. Th...

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Bibliographic Details
Published in:Metabolic brain disease 2015-08, Vol.30 (4), p.979-988
Main Authors: Cheng, Yue, Huang, Lixiang, Zhang, Xiaodong, Zhong, Jianhui, Ji, Qian, Xie, Shuangshuang, Chen, Lihua, Zuo, Panli, Zhang, Long Jiang, Shen, Wen
Format: Article
Language:English
Subjects:
Adult
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Cognition - physiology
Female
Humans
Liver Cirrhosis - metabolism
Liver Cirrhosis - surgery
Liver Transplantation - trends
Magnetic Resonance Imaging - trends
Male
Metabolic Diseases
Middle Aged
Neurology
Neurosciences
Oncology
Research Article
Rest - physiology
Time Factors
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Summary:To investigate the short-term brain activity changes in cirrhotic patients with Liver transplantation (LT) using resting-state functional MRI (fMRI) with regional homogeneity (ReHo) method. Twenty-six cirrhotic patients as transplant candidates and 26 healthy controls were included in this study. The assessment was repeated for a sub-group of 12 patients 1 month after LT. ReHo values were calculated to evaluate spontaneous brain activity and whole brain voxel-wise analysis was carried to detect differences between groups. Correlation analyses were performed to explore the relationship between the change of ReHo with the change of clinical indexes pre- and post-LT. Compared to pre-LT, ReHo values increased in the bilateral inferior frontal gyrus (IFG), right inferior parietal lobule (IPL), right supplementary motor area (SMA), right STG and left middle frontal gyrus (MFG) in patients post-LT. Compared to controls, ReHo values of post-LT patients decreased in the right precuneus, right SMA and increased in bilateral temporal pole, left caudate, left MFG, and right STG. The changes of ReHo in the right SMA, STG and IFG were correlated with change of digit symbol test (DST) scores ( P  
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-015-9657-1