Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules

A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excell...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2015-09, Vol.7 (34), p.19390-19397
Main Authors: Li, Zhanfeng, Yang, Ting, Lin, Chunming, Li, Quanshun, Liu, Songfeng, Xu, Fengzhi, Wang, Hongyan, Cui, Xuejun
Format: Article
Language:English
Subjects:
Animals
Cattle
Cell Line, Tumor
Delayed-Action Preparations
Flow Cytometry
Folic Acid - pharmacology
Glutathione - chemistry
Humans
Hydrophobic and Hydrophilic Interactions
Magnetic Phenomena
Nanocapsules - chemistry
Nanocapsules - ultrastructure
Particle Size
Serum Albumin, Bovine - chemistry
Sonication - methods
Spectrophotometry, Ultraviolet
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Summary:A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.5b05558