Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report

Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis/anhidrosis (AIGA) includes idiopathic pure sudomotor failure (IPSF), which has the following distinct features: sudden onset in youth, increa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dermatology 2015-09, Vol.42 (9), p.900-902
Main Authors: Honma, Masaru, Iinuma, Shin, Kanno, Kyoko, Komatsu, Shigetsuna, Minami-Hori, Masako, Ishida-Yamamoto, Akemi
Format: Article
Language:English
Subjects:
Adult
anhidrosis
carcinoembryonic antigen
Carcinoembryonic Antigen - blood
carcinoembryonic antigen-related cell adhesion molecule
clinical marker
Female
Glucocorticoids - administration & dosage
Humans
hypohidrosis
Hypohidrosis - blood
Hypohidrosis - drug therapy
Hypohidrosis - immunology
Methylprednisolone - administration & dosage
Pulse Therapy, Drug
sweat gland
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis/anhidrosis (AIGA) includes idiopathic pure sudomotor failure (IPSF), which has the following distinct features: sudden onset in youth, increased serum immunoglobulin E and responds favorably to systemic corticosteroid. No clinical markers reflecting the disease severity or activity have been established. Here, we report a case of AIGA in a Japanese patient successfully treated with repeated methylprednisolone pulse therapy. In this case, serum carcinoembryonic antigen (CEA) levels increased up to 19.8 ng/mL along with aberrant CEA immunoreactivity of eccrine sweat glands. Interestingly, the serum CEA level normalized as sweating improved with repeated methylprednisolone pulse therapy. Therefore, serum CEA level may serve as a useful clinical marker of hypohidrosis or anhidrosis.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.12926