Clinical and histological characteristics of canine ocular gliovascular syndrome

• Published in: Veterinary ophthalmology 2015-09, Vol.18 (5), p.371-380
• Main Authors: Treadwell, Amy, Naranjo, Carolina, Blocker, Tiffany, Zarfoss, Mitzi, Dubielzig, Richard R.
• Format: Article
• Language: English
• Subjects: Animals; canine ocular gliovascular syndrome; dog; Dog Diseases - diagnosis; Dog Diseases - pathology; Dogs; Female; Glaucoma, Neovascular - diagnosis; Glaucoma, Neovascular - pathology; Glaucoma, Neovascular - veterinary; glial cells; intraocular hemorrhage; intravitreal membranes; Male; neovascular glaucoma; Neovascularization, Pathologic - diagnosis; Neovascularization, Pathologic - pathology; Neovascularization, Pathologic - veterinary; Retrospective Studies; Syndrome; Vitreous Body - blood supply; Vitreous Body - pathology; Vitreous Hemorrhage - diagnosis; Vitreous Hemorrhage - pathology; Vitreous Hemorrhage - veterinary
• ISSN: 1463-5216; 1463-5224
• DOI: 10.1111/vop.12209

OBJECTIVE: To characterize the clinical, diagnostic, and histopathologic findings in dogs with canine ocular gliovascular syndrome (COGS). PROCEDURES: The archives at the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) were used to identify eyes with COGS. Histopathological inclusion criteria included: a neovascular membrane extending from the optic nerve head or retina, clusters of spindle cells lacking vascularization within the vitreous, and histological signs of glaucoma. Special and immunohistochemical (IHC) staining techniques were performed. Clinical data, treatments, and outcomes were obtained from case records and information provided by submitting veterinarians. RESULTS: Thirty‐seven eyes of 36 dogs were identified with COGS. The average age at diagnosis was 8.8 years (±2.2). The relative risk for a Labrador retriever affected by COGS was significantly greater (9.3 times) (P