Calix[4]pyrroles with Shortest Possible Strap: Exclusively Selective toward Fluoride Ion

Four new calix[4]­pyrroles with the shortest possible strap so far through ortho-linking of the aromatic unit have been synthesized, including a naphthalene-derived fluorescent receptor. They show exclusive selectivity toward the fluoride ion as confirmed by 1H NMR, isothermal titration calorimetry,...

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Bibliographic Details
Published in:Organic letters 2015-09, Vol.17 (17), p.4140-4143
Main Authors: Samanta, Ritwik, Kumar, B. Sathish, Panda, Pradeepta K
Format: Article
Language:English
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Summary:Four new calix[4]­pyrroles with the shortest possible strap so far through ortho-linking of the aromatic unit have been synthesized, including a naphthalene-derived fluorescent receptor. They show exclusive selectivity toward the fluoride ion as confirmed by 1H NMR, isothermal titration calorimetry, and fluorescence spectroscopic study. Anion affinity could also be modulated further via functionalization at the strap. Computational analysis displays calix[4]­pyrroles binding to fluoride ion in a very unusual 1,3-alternate conformation where the anion resides on the opposite side of the strap.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01866