Copper-Catalyzed Ligand-Free Amidation of Benzylic Hydrocarbons and Inactive Aliphatic Alkanes

An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides was developed. The protocol proceeded smoothly without any ligand, and a wide range of N-alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yield...

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Bibliographic Details
Published in:Organic letters 2015-09, Vol.17 (17), p.4276-4279
Main Authors: Zeng, Hui-Ting, Huang, Jing-Mei
Format: Article
Language:English
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Summary:An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides was developed. The protocol proceeded smoothly without any ligand, and a wide range of N-alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02063