Exotines A and B, Two Heterodimers of Isopentenyl-Substituted Indole and Coumarin Derivatives from Murraya exotica

Exotines A and B (1 and 2), two heterodimers of isopentenyl-substituted indole and coumarin derivatives linked through a new fused heptacyclic ring system, were isolated from the roots of Murraya exotica. Their structures were established by comprehensive NMR and MS spectroscopic data analysis, and...

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Bibliographic Details
Published in:Organic letters 2015-09, Vol.17 (17), p.4380-4383
Main Authors: Liu, Bing-Yu, Zhang, Chen, Zeng, Ke-Wu, Li, Jun, Guo, Xiao-Yu, Zhao, Ming-Bo, Tu, Peng-Fei, Jiang, Yong
Format: Article
Language:English
Subjects:
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
Glycosides
Indoles - chemistry
Indoles - isolation & purification
Indoles - pharmacology
Inhibitory Concentration 50
Lipopolysaccharides - pharmacology
Microglia - drug effects
Molecular Structure
Murraya - chemistry
Nitric Oxide - biosynthesis
Nuclear Magnetic Resonance, Biomolecular
Plant Roots - chemistry
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Summary:Exotines A and B (1 and 2), two heterodimers of isopentenyl-substituted indole and coumarin derivatives linked through a new fused heptacyclic ring system, were isolated from the roots of Murraya exotica. Their structures were established by comprehensive NMR and MS spectroscopic data analysis, and the absolute configurations were determined by single-crystal X-ray crystallographic analysis and ECD calculations. Compounds 1 and 2 showed inhibition of nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells with IC50 values of 9.2 and 39.9 μM, respectively.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02230