Brain Endothelial Cell Targeting Via a Peptide-Functionalized Liposomal Carrier for Xenon Hyper-CEST MRI

A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper‐CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of...

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Bibliographic Details
Published in:Advanced healthcare materials 2015-01, Vol.4 (1), p.40-45
Main Authors: Schnurr, Matthias, Sydow, Karl, Rose, Honor May, Dathe, Margitta, Schröder, Leif
Format: Article
Language:English
Subjects:
blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - metabolism
Brain
Carriers
Cells, Cultured
Contrast agents
Endothelial cells
Endothelial Cells - diagnostic imaging
Endothelial Cells - metabolism
Health care
Human
Humans
Liposomes
Magnetic Resonance Angiography
MRI
nanocarriers
Peptides - chemistry
Peptides - pharmacology
Radiography
Solubility
Xenon
xenon Hyper-CEST
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Description
Summary:A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper‐CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201400224