Brain Endothelial Cell Targeting Via a Peptide-Functionalized Liposomal Carrier for Xenon Hyper-CEST MRI

A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper‐CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of...

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Published in:Advanced healthcare materials 2015-01, Vol.4 (1), p.40-45
Main Authors: Schnurr, Matthias, Sydow, Karl, Rose, Honor May, Dathe, Margitta, Schröder, Leif
Format: Article
Language:English
Subjects:
blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - metabolism
Brain
Carriers
Cells, Cultured
Contrast agents
Endothelial cells
Endothelial Cells - diagnostic imaging
Endothelial Cells - metabolism
Health care
Human
Humans
Liposomes
Magnetic Resonance Angiography
MRI
nanocarriers
Peptides - chemistry
Peptides - pharmacology
Radiography
Solubility
Xenon
xenon Hyper-CEST
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cited_by cdi_FETCH-LOGICAL-c4774-1bbfb3e70b4f9f8978385151eb19a6080cddc0b9bed06c847283440b5475907a3
cites cdi_FETCH-LOGICAL-c4774-1bbfb3e70b4f9f8978385151eb19a6080cddc0b9bed06c847283440b5475907a3
container_end_page 45
container_issue 1
container_start_page 40
container_title Advanced healthcare materials
container_volume 4
creator Schnurr, Matthias
Sydow, Karl
Rose, Honor May
Dathe, Margitta
Schröder, Leif
description A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper‐CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.
doi_str_mv 10.1002/adhm.201400224
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subjects blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - metabolism
Brain
Carriers
Cells, Cultured
Contrast agents
Endothelial cells
Endothelial Cells - diagnostic imaging
Endothelial Cells - metabolism
Health care
Human
Humans
Liposomes
Magnetic Resonance Angiography
MRI
nanocarriers
Peptides - chemistry
Peptides - pharmacology
Radiography
Solubility
Xenon
xenon Hyper-CEST
title Brain Endothelial Cell Targeting Via a Peptide-Functionalized Liposomal Carrier for Xenon Hyper-CEST MRI
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