Metal-Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci-Type Alkylation of Various Heterocycles

A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready av...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-06, Vol.357 (9), p.2055-2060
Main Authors: Tang, Ren-Jin, Kang, Lei, Yang, Luo
Format: Article
Language:English
Subjects:
Aldehydes
Aliphatic compounds
Alkylation
Availability
Biocompatibility
decarbonylation
heterocycles
Joining
metal-free conditions
Radicals
Synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal‐free conditions and broad substrate scope should make this method attractive for the late‐stage alkylation of bioactive heterocycles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500268