An anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu super(2+) and PPi, real-time ALP assaying and cell imaging

A Cu super(2+) ensemble polyfluorene derivative, poly[5,5'-(((9H-fluorene-9,9-diyl)bis(hexan e-6,1-diyl))bis(oxy))diisophthalate] sodium salt (PFT), displays unprecedented selectivity for PPi (LOD = 2.26 ppb) in aqueous solution as well as in random urine samples at physiological pH vis-a-vis m...

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Bibliographic Details
Published in:Analyst (London) 2015-06, Vol.140 (13), p.4388-4392
Main Authors: Malik, Akhtar H, Hussain, Sameer, Tanwar, Arvin Sain, Layek, Sourav, Trivedi, Vishal, Iyer, Parameswar K
Format: Article
Language:English
Subjects:
Aqueous solutions
Derivatives
Displays
Human
Imaging
Macrophages
Real time
Urine
Online Access:Get full text
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Summary:A Cu super(2+) ensemble polyfluorene derivative, poly[5,5'-(((9H-fluorene-9,9-diyl)bis(hexan e-6,1-diyl))bis(oxy))diisophthalate] sodium salt (PFT), displays unprecedented selectivity for PPi (LOD = 2.26 ppb) in aqueous solution as well as in random urine samples at physiological pH vis-a-vis monitoring ALP activity. Furthermore, intracellular imaging of Cu super(2+) and PPi in mouse macrophage (J774A.1) and human breast cancer cells (MDA-MB231) was achieved to confirm the viability of PFT in biological systems.
ISSN:0003-2654
1364-5528
DOI:10.1039/c5an00905g