Direct ortho-Hydroxylation of 2-Phenylpyridines using Palladium(II) Chloride and Hydrogen Peroxide

Direct functionalization of the ubiquitous CH bond is receiving much attention because complex structures can be formed from simple precursors. This paper reports a useful method for the direct hydroxylation of 2‐phenylpyridines using palladium(II) chloride and aqueous hydrogen peroxide. In this me...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-06, Vol.357 (9), p.2017-2021
Main Authors: Yamaguchi, Tomoaki, Yamaguchi, Eiji, Tada, Norihiro, Itoh, Akichika
Format: Article
Language:English
Subjects:
Activation
Bonding
Chlorides
CH activation
Derivatives
Hydrogen peroxide
Hydroxylation
palladium
peroxides
Precursors
Receiving
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Summary:Direct functionalization of the ubiquitous CH bond is receiving much attention because complex structures can be formed from simple precursors. This paper reports a useful method for the direct hydroxylation of 2‐phenylpyridines using palladium(II) chloride and aqueous hydrogen peroxide. In this method, hydrogen peroxide, which has high atom efficiency, is employed as the oxidant and phenol derivatives are generated via CH activation.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500061