Glass capillary nanopore for single molecule detection

Single molecule detection based on nanopore technology is a very promising approach for medical diagnostics, drug therapy and even DNA sequencing. Compared with other biological nanopores and solid-state nanopores, the glass capillary nanopore has low cost, easy availability and stable mechanical ch...

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Bibliographic Details
Published in:Science China. Technological sciences 2015-05, Vol.58 (5), p.803-812
Main Authors: Sha, JingJie, Si, Wei, Xu, Wei, Zou, YiRen, Chen, YunFei
Format: Article
Language:English
Subjects:
Availability
Capillarity
China
Deoxyribonucleic acid
Diagnostic systems
DNA分子
DNA测序
Engineering
Glass
Nanoparticles
Nanostructure
Review
医学诊断
单分子检测
机械特性
玻璃毛细管
纳米孔
药物治疗
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Description
Summary:Single molecule detection based on nanopore technology is a very promising approach for medical diagnostics, drug therapy and even DNA sequencing. Compared with other biological nanopores and solid-state nanopores, the glass capillary nanopore has low cost, easy availability and stable mechanical characteristics, thus it has been widely used in the nanopore technology for single molecule detection. In this review, we will focus on the studies of the glass nanopore sensors. The popular glass nanopore fabrication methods would be introduced, and the applications of glass nanopores in the detection of nanoparticles, proteins and DNA molecules would be presented. We hope this review will help widen field of vision and promote the development of the nanopore technology based on the glass capillary nanopores.
ISSN:1674-7321
1869-1900
DOI:10.1007/s11431-015-5779-2