Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril

Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC[8]), possessing a barrel-shaped cavity, has been prepared in high yield on a gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6]. In either case, a dynamic covalent library is first generated from which...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (54), p.10921-10924
Main Authors: Prigorchenko, E, Öeren, M, Kaabel, S, Fomitšenko, M, Reile, I, Järving, I, Tamm, T, Topić, F, Rissanen, K, Aav, R
Format: Article
Language:English
Subjects:
Amplification
Anions
Covalence
Dynamics
Formaldehyde
Holes
Libraries
Synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC[8]), possessing a barrel-shaped cavity, has been prepared in high yield on a gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6]. In either case, a dynamic covalent library is first generated from which the desired cycHC can be amplified using a suitable anion template.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04101e