Incorporation of ionic liquid into porous polymer monoliths to enhance the separation of small molecules in reversed-phase high-performance liquid chromatography

An ionic liquid was incorporated into the porous polymer monoliths to afford stationary phases with enhanced chromatographic performance for small molecules in reversed‐phase high‐performance liquid chromatography. The effect of the ionic liquid in the polymerization mixture on the performance of th...

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Bibliographic Details
Published in:Journal of separation science 2015-06, Vol.38 (12), p.2101-2108
Main Authors: Wang, Jiafei, Bai, Ligai, Wei, Zhen, Qin, Junxiao, Ma, Yamin, Liu, Haiyan
Format: Article
Language:English
Subjects:
Chromatography
Efficiency
High-performance liquid chromatography
Hydrocarbons
Ionic liquids
Ions
Isomers
Liquid chromatography
Phases
Polymerization
Porous polymer monoliths
Reversed phase
Separation
Small molecule separations
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Summary:An ionic liquid was incorporated into the porous polymer monoliths to afford stationary phases with enhanced chromatographic performance for small molecules in reversed‐phase high‐performance liquid chromatography. The effect of the ionic liquid in the polymerization mixture on the performance of the monoliths was studied in detail. While monoliths without ionic liquid exhibited poor resolution and low efficiency, the addition of ionic liquid to the polymerization mixture provides highly increased resolution and high efficiency. The chromatographic performances of the monoliths were demonstrated by the separations of various small molecules including aromatic hydrocarbons, isomers, and homologues using a binary polar mobile phase. The present column efficiency reached 27 000 plates/m, which showed that the ionic liquid monoliths are alternative stationary phases in the separation of small molecules by high‐performance liquid chromatography
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201500061