Comparative real-time study of cellular uptake of a formulated conjugated linolenic acid rich nano and conventional macro emulsions and their bioactivity in ex vivo models for parenteral applications

•Colloidal nanotechnology: Fabrication of a stable ESA-NE system.•Nanoparticle uptake: real-time tracking & interpretation.•Corroborative Evidence: metabolic fate of size dependent ESA rich TG formulations.•Fluorescence imaging & cytometric data: role of ESA in countering oxidative stress. T...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-02, Vol.126, p.426-436
Main Authors: Paul, Debjyoti, Mukherjee, Sayani, Chakraborty, Rajarshi, Mallick, Sanjaya K., Dhar, Pubali
Format: Article
Language:English
Subjects:
alpha-Linolenic Acid - chemistry
alpha-Linolenic Acid - pharmacology
Cell Death - drug effects
Cell Survival - drug effects
Cellular
Dose-Response Relationship, Drug
Effectiveness
Emulsions
Emulsions - chemistry
Emulsions - pharmacology
Flow cytometry
Humans
Leukocytes, Mononuclear - chemistry
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - metabolism
Linolenic acid
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Mathematical models
Nanoemulsion
Nanostructure
Nanostructures - chemistry
Particle Size
Reactive oxygen species
Reactive Oxygen Species - metabolism
Real time
Structure-Activity Relationship
Surface Properties
Time Factors
Transmission electron microscopy
Uptakes
α-Eleostearic acid
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Summary:•Colloidal nanotechnology: Fabrication of a stable ESA-NE system.•Nanoparticle uptake: real-time tracking & interpretation.•Corroborative Evidence: metabolic fate of size dependent ESA rich TG formulations.•Fluorescence imaging & cytometric data: role of ESA in countering oxidative stress. The objective of the present study was to fabricate and monitor real-time, impact of a stable conjugated linolenic acid, α-eleostearic acid (ESA) rich nanoemulsion (NE) formulation (d
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2014.12.046