Preparation and characterization of biofunctionalized chitosan/Fe sub(3)O sub(4) magnetic nanoparticles for application in liver magnetic resonance imaging

Biofunctionalized chitosan[at]Fe sub(3)O sub(4) nanoparticles are synthesized by combining Fe sub(3)O sub(4) and CS chemically modified with PEG and lactobionic acid in one step. The biofunctionalized nanoparticles are characterized by TEM, X-ray, DLS, zeta-potential and magnetic measurements. The i...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2015-08, Vol.388, p.116-122
Main Authors: Song, Xiaoli, Luo, Xiadan, Zhang, Qingqing, Zhu, Aiping, Ji, Lijun, Yan, Caifeng
Format: Article
Language:English
Subjects:
Biocompatibility
Chitosan
In vitro testing
Liver
Magnetic resonance imaging
Nanoparticles
Surgical implants
Toxicity
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Summary:Biofunctionalized chitosan[at]Fe sub(3)O sub(4) nanoparticles are synthesized by combining Fe sub(3)O sub(4) and CS chemically modified with PEG and lactobionic acid in one step. The biofunctionalized nanoparticles are characterized by TEM, X-ray, DLS, zeta-potential and magnetic measurements. The in vitro and in vivo behaviors of the biofunctionalized nanoparticles, especially, the cytotoxicity, the protein resistance, metabolism and iron toxicity are assessed. The functional groups, PEG enable the nanoparticles more biocompatible and the lactobionic acid groups enable liver targeting. The potential applications of the nanoparticles in liver magnetic resonance imaging are confirmed. The results demonstrated that the nanoparticles are suspension stability, non-cytotoxicity, non-tissue toxicity and sensitive in liver magnetic resonance imaging, representing potential tools for applications in the biomedical field.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2015.04.017