Continuous and surfactant-free preparation of nanocapsulized proteins

In this study, we demonstrate the preparation of nanocapsules using the self-assembly of preformed polymers at the interface of a three-way controlled laminated stream flow in a microchannel. The production process occurs without the use of surfactants and allows the regulation of nanocapsule size w...

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Bibliographic Details
Published in:Microfluidics and nanofluidics 2012-07, Vol.13 (1), p.141-149
Main Authors: Kim, Hyung Hoon, Kim, Eun Yeong, Park, Jin Cheol, Chang, Seung-Cheol, Park, Young Joon, Morten, Karl, Go, Jeung Sang
Format: Article
Language:English
Subjects:
Acetone
Analytical Chemistry
Aspect ratio
Bacteria
Biological and medical sciences
Biomedical Engineering and Bioengineering
Channels
Engineering
Engineering Fluid Dynamics
Garbage collection
General pharmacology
Medical sciences
Microchannels
Nanocomposites
Nanomaterials
Nanostructure
Nanotechnology and Microengineering
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers
Research Paper
Solvents
Stream discharge
Stream flow
Surfactants
Velocity distribution
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Summary:In this study, we demonstrate the preparation of nanocapsules using the self-assembly of preformed polymers at the interface of a three-way controlled laminated stream flow in a microchannel. The production process occurs without the use of surfactants and allows the regulation of nanocapsule size with solvent recycling. Problems associated with nanocapsule attachment to the channel surface disturbing the lamination flow and producing nanocapsules of poor quality were overcome by altering the microchannel aspect ratio. The aspect ratio was altered by considering the mixing ratio and velocity distribution on the cross section along the microchannel. Modeling and practical experiment identified the aspect ratio of the microchannel of 1.6 as producing clear lamination flow. Ovalbumin-encapsulated nanocapsules were produced with a narrow size distribution of
ISSN:1613-4982
1613-4990
DOI:10.1007/s10404-012-0952-4