Bone strength and acetylcholinesterase inhibition as endpoints in chlorpyrifos toxicity to Fundulus heteroclitus

Brain acetylcholinesterase (AChE) inhibition was measured during 4-week and 4-day episodic exposures to chlorpyrifos. Organisms were exposed to a seawater (-) control, an acetone (+) control (0.1%), and 0.625, 1.25, 2.5, 5.0. and 10.0 microgram of chlorpyrifos(.)L-1 in each test. These episodic expo...

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Bibliographic Details
Published in:Pesticide biochemistry and physiology 1998-08, Vol.60 (3), p.167-175
Main Authors: Karen, D.J. (Clemson University, Pendleton, SC.), Draughn, R, Fulton, M, Ross, P
Format: Article
Language:English
Subjects:
ACETILCOLINESTERASA
ACETYLCHOLINESTERASE
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Agnatha. Pisces
Animal, plant and microbial ecology
Applied ecology
AQUATIC TOXICOLOGY
BIOASSAYS
Biological and medical sciences
BONES
BRAIN
CEREBRO
CHLORPYRIFOS
CLORPIRIFOS
CYPRINODONTIFORMES
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
ENCEPHALE
ENSAYO BIOLOGICO
ENZYMIC ACTIVITY
EXPOSURE
Fundamental and applied biological sciences. Psychology
Fundulus heteroclitus
HUESOS
INHIBICION
INHIBITION
MUSCULOSKELETAL SYSTEM
RESISTANCE MECANIQUE
RESISTENCIA MECANICA
SISTEMA OSEOMUSCULAR
SKELETOMUSCULAR SYSTEM
SQUELETTE ET MUSCULATURE
STRENGTH
TEST BIOLOGIQUE
TOXICIDAD
TOXICITE
TOXICITY
TOXICOLOGIA
TOXICOLOGIE
TOXICOLOGY
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Summary:Brain acetylcholinesterase (AChE) inhibition was measured during 4-week and 4-day episodic exposures to chlorpyrifos. Organisms were exposed to a seawater (-) control, an acetone (+) control (0.1%), and 0.625, 1.25, 2.5, 5.0. and 10.0 microgram of chlorpyrifos(.)L-1 in each test. These episodic exposures significantly depressed AChE activity at 2.5, 5.0. and 10.0 microgram(.)L-1 (weekly test) and at 1.25, 2.5, 5.0, and 10.0 microgram(.)L-1 (daily test). Six-hour pulsed exposure to chlorpyrifos inhibited brain AChE activity at concentrations as low as 1.25 microgram(.)L-1. Stress at failure of caudal vertebrae following episodic exposure was also tested. Analysis of samples from daily 6-h treatments found no differences after 2 days, however, vertebrae were significantly weaker (than controls) after 4 days. Analysis of weekly 6-h exposures found weaker caudal vertebrae after 2 weeks but not after 4 weeks
ISSN:0048-3575
1095-9939
DOI:10.1006/pest.1998.2345