Immunomodulatory effects of interferon- beta -1b in vivo: induction of the expression of transforming growth factor- beta 1 and its receptor type II

The mechanisms by which interferon-beta-1b (IFN beta -1b) acts in the treatment of patients with multiple sclerosis (MS) are not completely known. A total of 10 MS patients were treated with 8 million units of IFN beta -1b every other day. Compared to baseline and control group the expression of TGF...

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Bibliographic Details
Published in:Journal of neuroimmunology 1998-11, Vol.91 (1-2), p.73-81
Main Authors: Ossege, L M, Sindern, E, Patzold, T, Malin, J P
Format: Article
Language:English
Online Access:Get full text
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Summary:The mechanisms by which interferon-beta-1b (IFN beta -1b) acts in the treatment of patients with multiple sclerosis (MS) are not completely known. A total of 10 MS patients were treated with 8 million units of IFN beta -1b every other day. Compared to baseline and control group the expression of TGF beta -1-mRNA by PBMC was persistently increased at week 6, month 3 and month 6 (p less than or equal to 0.04), that of the TGF beta -1 receptor type II from day 5 up to month 6 (p
ISSN:0165-5728
DOI:10.1016/S0165-5728(98)00154-4