Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer

Highlights • Increased expression of TFEB is linked with increased LAMP2a and Cathepsin-D expression. • Lysosomal markers are more frequently overexpressed in adenocarcinomas. • Increased expression of TFEB, LAMP2a and Cathepsin-D related with poor prognosis. • Silencing of TFEB with siRNAs in lung...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-10, Vol.90 (1), p.98-105
Main Authors: Giatromanolaki, Alexandra, Kalamida, Dimitra, Sivridis, Efthimios, Karagounis, Ilias V, Gatter, Kevin C, Harris, Adrian L, Koukourakis, Michael I
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Autophagy
Autophagy - physiology
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Cathepsin D
Cathepsin D - biosynthesis
Cathepsin D - genetics
Cell Line, Tumor
Cell Movement - physiology
Female
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
LAMP2a
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Lysosomal-Associated Membrane Protein 2 - biosynthesis
Lysosomal-Associated Membrane Protein 2 - genetics
Lysosomes
Lysosomes - enzymology
Lysosomes - metabolism
Male
Middle Aged
Neoplasm Staging
Phenotype
Prognosis
Pulmonary/Respiratory
TFEB
Treatment Outcome
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Summary:Highlights • Increased expression of TFEB is linked with increased LAMP2a and Cathepsin-D expression. • Lysosomal markers are more frequently overexpressed in adenocarcinomas. • Increased expression of TFEB, LAMP2a and Cathepsin-D related with poor prognosis. • Silencing of TFEB with siRNAs in lung cancer cell lines resulted in reduced migration ability.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2015.07.008