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Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer
Highlights • Increased expression of TFEB is linked with increased LAMP2a and Cathepsin-D expression. • Lysosomal markers are more frequently overexpressed in adenocarcinomas. • Increased expression of TFEB, LAMP2a and Cathepsin-D related with poor prognosis. • Silencing of TFEB with siRNAs in lung...
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| Published in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-10, Vol.90 (1), p.98-105 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c490t-6760b0f875142832c6ad161e35cfa44af8c4c848632eee490a47f4aa1742ec643 |
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| cites | cdi_FETCH-LOGICAL-c490t-6760b0f875142832c6ad161e35cfa44af8c4c848632eee490a47f4aa1742ec643 |
| container_end_page | 105 |
| container_issue | 1 |
| container_start_page | 98 |
| container_title | Lung cancer (Amsterdam, Netherlands) |
| container_volume | 90 |
| creator | Giatromanolaki, Alexandra Kalamida, Dimitra Sivridis, Efthimios Karagounis, Ilias V Gatter, Kevin C Harris, Adrian L Koukourakis, Michael I |
| description | Highlights • Increased expression of TFEB is linked with increased LAMP2a and Cathepsin-D expression. • Lysosomal markers are more frequently overexpressed in adenocarcinomas. • Increased expression of TFEB, LAMP2a and Cathepsin-D related with poor prognosis. • Silencing of TFEB with siRNAs in lung cancer cell lines resulted in reduced migration ability. |
| doi_str_mv | 10.1016/j.lungcan.2015.07.008 |
| format | article |
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Kalamida, Dimitra ; Sivridis, Efthimios ; Karagounis, Ilias V ; Gatter, Kevin C ; Harris, Adrian L ; Koukourakis, Michael I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-6760b0f875142832c6ad161e35cfa44af8c4c848632eee490a47f4aa1742ec643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autophagy</topic><topic>Autophagy - physiology</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Cathepsin D</topic><topic>Cathepsin D - biosynthesis</topic><topic>Cathepsin D - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - physiology</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>LAMP2a</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Lysosomal-Associated Membrane Protein 2 - biosynthesis</topic><topic>Lysosomal-Associated Membrane Protein 2 - genetics</topic><topic>Lysosomes</topic><topic>Lysosomes - enzymology</topic><topic>Lysosomes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Pulmonary/Respiratory</topic><topic>TFEB</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giatromanolaki, Alexandra</creatorcontrib><creatorcontrib>Kalamida, Dimitra</creatorcontrib><creatorcontrib>Sivridis, Efthimios</creatorcontrib><creatorcontrib>Karagounis, Ilias V</creatorcontrib><creatorcontrib>Gatter, Kevin C</creatorcontrib><creatorcontrib>Harris, Adrian L</creatorcontrib><creatorcontrib>Koukourakis, Michael I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giatromanolaki, Alexandra</au><au>Kalamida, Dimitra</au><au>Sivridis, Efthimios</au><au>Karagounis, Ilias V</au><au>Gatter, Kevin C</au><au>Harris, Adrian L</au><au>Koukourakis, Michael I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>90</volume><issue>1</issue><spage>98</spage><epage>105</epage><pages>98-105</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>Highlights • Increased expression of TFEB is linked with increased LAMP2a and Cathepsin-D expression. • Lysosomal markers are more frequently overexpressed in adenocarcinomas. • Increased expression of TFEB, LAMP2a and Cathepsin-D related with poor prognosis. • Silencing of TFEB with siRNAs in lung cancer cell lines resulted in reduced migration ability.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26264650</pmid><doi>10.1016/j.lungcan.2015.07.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Autophagy Autophagy - physiology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Cathepsin D Cathepsin D - biosynthesis Cathepsin D - genetics Cell Line, Tumor Cell Movement - physiology Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry LAMP2a Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - surgery Lysosomal-Associated Membrane Protein 2 - biosynthesis Lysosomal-Associated Membrane Protein 2 - genetics Lysosomes Lysosomes - enzymology Lysosomes - metabolism Male Middle Aged Neoplasm Staging Phenotype Prognosis Pulmonary/Respiratory TFEB Treatment Outcome |
| title | Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer |
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