Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing

Highlights • We review thebiomolecular relationship between cellular senescence, ageing and cancer. • Pro-inflammatory and oxidative senescence status induces tumour-promoting microenvironment.Ageing-related cellular senescence may either suppress or promote tumour progression. • Cell signalling pat...

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Bibliographic Details
Published in:Ageing research reviews 2015-09, Vol.23 (Pt B), p.125-138
Main Authors: Badiola, Iker, Santaolalla, Francisco, Garcia-Gallastegui, Patricia, Ana, Sánchez-del Rey, Unda, Fernando, Ibarretxe, Gaskon
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - metabolism
Aging - pathology
Animals
Cellular Senescence - genetics
Cellular Senescence - physiology
Epigenesis, Genetic
Humans
Internal Medicine
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neurology
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Summary:Highlights • We review thebiomolecular relationship between cellular senescence, ageing and cancer. • Pro-inflammatory and oxidative senescence status induces tumour-promoting microenvironment.Ageing-related cellular senescence may either suppress or promote tumour progression. • Cell signalling pathways altered duringAlterations in cell signalling associated to ageing and cancer may be reversible.ageing and cancer may be reversible mechanisms. • The first clinical trials of micro-RNA therapy against cancer are already on their way. • We discuss biomolecular therapeutic strategies to treat cancer linked to ageing.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2015.03.004