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Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study
Aim The aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses. Material and Methods A prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal...
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| Published in: | The journal of obstetrics and gynaecology research 2015-09, Vol.41 (9), p.1330-1336 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Melo, Nayana Alves De Brito Araujo Júnior, Edward Helfer, Talita Micheletti Caetano, Ana Carolina Rabachini Zamarian, Ana Cristina Perez Moron, Antonio Fernandes Diniz, Angélica Lemos Debs Nardozza, Luciano Marcondes Machado |
| description | Aim
The aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses.
Material and Methods
A prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal fetuses) between 32 and 40 weeks of gestation. FGR diagnosis was based on an estimated fetal weight below the 10th percentile of the Hadlock curve. Ophthalmic artery Doppler images were obtained with a linear transducer, with color Doppler examination of the region medial to the optic nerve. The following indices were obtained: pulsatility index, resistance index, peak systolic velocity, second peak velocity (P2), end diastolic velocity, and P2 / peak systolic velocity ratio. The Mann–Whitney U‐test and Student's t‐test were used to compare the groups with regard to quantitative variables, and the χ2‐test was used for categorical variables.
Results
Pulsatility index and resistance index were significantly lower in pregnant women with FGR than in those with normal fetuses, with P |
| doi_str_mv | 10.1111/jog.12739 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1710656714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1710656714</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4579-830844a9110c844938dccc3e9f2b8bff5e799366829a0f53c9539777200c05923</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxiMEon_gwAsgH-GQ1o4dO-a2WmABVfQChZvl9U52XZI42I6WPEtfllm27Q1L1oxmfvPJnq8oXjF6wfBc3obtBasU10-KUyaEKqmq5VPMuWBlQ5U8Kc5SuqWUKc2a58VJJakQupKnxd0iJUiphyGT0JLeZoiD7cj7MI4dRDLaaHvAYjq0w7jLO9v13hEbsTgTP5AW8oQaZO_zjmxj2GOIkHL0LvswHJC8A7w-bghWe-yhMsqNEbaDHdz8jiyIswlKF4YcQ0dSnjbzi-JZa7sEL-_jefH944dvy0_l1fXq83JxVTpRK102nDZCWM0YdZho3myccxx0W62bddvWoLTmUjaVtrStudM110qpilJHa13x8-LNUXeM4feErzO9Tw66zg4QpmSYYlTWUjGB6Nsj6mJIKUJrRvyQjbNh1By8MOiF-ecFsq_vZad1D5tH8mH5CFwegb3vYP6_kvlyvXqQLI8THlf453HCxl9GKq5q8-PrylRM3SxXN9L85H8BG2qkug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1710656714</pqid></control><display><type>article</type><title>Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study</title><source>Wiley</source><creator>Melo, Nayana Alves De Brito ; Araujo Júnior, Edward ; Helfer, Talita Micheletti ; Caetano, Ana Carolina Rabachini ; Zamarian, Ana Cristina Perez ; Moron, Antonio Fernandes ; Diniz, Angélica Lemos Debs ; Nardozza, Luciano Marcondes Machado</creator><creatorcontrib>Melo, Nayana Alves De Brito ; Araujo Júnior, Edward ; Helfer, Talita Micheletti ; Caetano, Ana Carolina Rabachini ; Zamarian, Ana Cristina Perez ; Moron, Antonio Fernandes ; Diniz, Angélica Lemos Debs ; Nardozza, Luciano Marcondes Machado</creatorcontrib><description>Aim
The aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses.
Material and Methods
A prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal fetuses) between 32 and 40 weeks of gestation. FGR diagnosis was based on an estimated fetal weight below the 10th percentile of the Hadlock curve. Ophthalmic artery Doppler images were obtained with a linear transducer, with color Doppler examination of the region medial to the optic nerve. The following indices were obtained: pulsatility index, resistance index, peak systolic velocity, second peak velocity (P2), end diastolic velocity, and P2 / peak systolic velocity ratio. The Mann–Whitney U‐test and Student's t‐test were used to compare the groups with regard to quantitative variables, and the χ2‐test was used for categorical variables.
Results
Pulsatility index and resistance index were significantly lower in pregnant women with FGR than in those with normal fetuses, with P < 0.001 in both indices. P2 and end diastolic velocity were significantly higher in pregnant women with FGR than in those with normal fetuses (P = 0.002 and P = 0.004, respectively). The P2 / peak systolic velocity ratio was significantly higher in the FGR group than in the control group (P < 0.001). In FGR subgroups, with (17 fetuses) and without (43 fetuses) uterine artery Doppler abnormalities, no significant changes were observed between the groups.
Conclusion
In the third trimester of pregnancy, we observed significant differences in the ophthalmic artery Doppler parameters of pregnant women with FGR compared with those with normal fetuses.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.12739</identifier><identifier>PMID: 26044926</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; Cross-Sectional Studies ; Doppler ; Echocardiography, Doppler ; Female ; fetal growth restriction ; Fetal Growth Retardation - diagnostic imaging ; Fetal Growth Retardation - physiopathology ; Gestational Age ; Humans ; ophthalmic artery ; Ophthalmic Artery - diagnostic imaging ; Ophthalmic Artery - physiopathology ; Pregnancy ; Pregnancy Trimester, Third ; Prospective Studies ; Ultrasonography, Prenatal ; uterine artery ; Young Adult</subject><ispartof>The journal of obstetrics and gynaecology research, 2015-09, Vol.41 (9), p.1330-1336</ispartof><rights>2015 Japan Society of Obstetrics and Gynecology</rights><rights>2015 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4579-830844a9110c844938dccc3e9f2b8bff5e799366829a0f53c9539777200c05923</citedby><cites>FETCH-LOGICAL-c4579-830844a9110c844938dccc3e9f2b8bff5e799366829a0f53c9539777200c05923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26044926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melo, Nayana Alves De Brito</creatorcontrib><creatorcontrib>Araujo Júnior, Edward</creatorcontrib><creatorcontrib>Helfer, Talita Micheletti</creatorcontrib><creatorcontrib>Caetano, Ana Carolina Rabachini</creatorcontrib><creatorcontrib>Zamarian, Ana Cristina Perez</creatorcontrib><creatorcontrib>Moron, Antonio Fernandes</creatorcontrib><creatorcontrib>Diniz, Angélica Lemos Debs</creatorcontrib><creatorcontrib>Nardozza, Luciano Marcondes Machado</creatorcontrib><title>Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J. Obstet. Gynaecol. Res</addtitle><description>Aim
The aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses.
Material and Methods
A prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal fetuses) between 32 and 40 weeks of gestation. FGR diagnosis was based on an estimated fetal weight below the 10th percentile of the Hadlock curve. Ophthalmic artery Doppler images were obtained with a linear transducer, with color Doppler examination of the region medial to the optic nerve. The following indices were obtained: pulsatility index, resistance index, peak systolic velocity, second peak velocity (P2), end diastolic velocity, and P2 / peak systolic velocity ratio. The Mann–Whitney U‐test and Student's t‐test were used to compare the groups with regard to quantitative variables, and the χ2‐test was used for categorical variables.
Results
Pulsatility index and resistance index were significantly lower in pregnant women with FGR than in those with normal fetuses, with P < 0.001 in both indices. P2 and end diastolic velocity were significantly higher in pregnant women with FGR than in those with normal fetuses (P = 0.002 and P = 0.004, respectively). The P2 / peak systolic velocity ratio was significantly higher in the FGR group than in the control group (P < 0.001). In FGR subgroups, with (17 fetuses) and without (43 fetuses) uterine artery Doppler abnormalities, no significant changes were observed between the groups.
Conclusion
In the third trimester of pregnancy, we observed significant differences in the ophthalmic artery Doppler parameters of pregnant women with FGR compared with those with normal fetuses.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Doppler</subject><subject>Echocardiography, Doppler</subject><subject>Female</subject><subject>fetal growth restriction</subject><subject>Fetal Growth Retardation - diagnostic imaging</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>ophthalmic artery</subject><subject>Ophthalmic Artery - diagnostic imaging</subject><subject>Ophthalmic Artery - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Prospective Studies</subject><subject>Ultrasonography, Prenatal</subject><subject>uterine artery</subject><subject>Young Adult</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxiMEon_gwAsgH-GQ1o4dO-a2WmABVfQChZvl9U52XZI42I6WPEtfllm27Q1L1oxmfvPJnq8oXjF6wfBc3obtBasU10-KUyaEKqmq5VPMuWBlQ5U8Kc5SuqWUKc2a58VJJakQupKnxd0iJUiphyGT0JLeZoiD7cj7MI4dRDLaaHvAYjq0w7jLO9v13hEbsTgTP5AW8oQaZO_zjmxj2GOIkHL0LvswHJC8A7w-bghWe-yhMsqNEbaDHdz8jiyIswlKF4YcQ0dSnjbzi-JZa7sEL-_jefH944dvy0_l1fXq83JxVTpRK102nDZCWM0YdZho3myccxx0W62bddvWoLTmUjaVtrStudM110qpilJHa13x8-LNUXeM4feErzO9Tw66zg4QpmSYYlTWUjGB6Nsj6mJIKUJrRvyQjbNh1By8MOiF-ecFsq_vZad1D5tH8mH5CFwegb3vYP6_kvlyvXqQLI8THlf453HCxl9GKq5q8-PrylRM3SxXN9L85H8BG2qkug</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Melo, Nayana Alves De Brito</creator><creator>Araujo Júnior, Edward</creator><creator>Helfer, Talita Micheletti</creator><creator>Caetano, Ana Carolina Rabachini</creator><creator>Zamarian, Ana Cristina Perez</creator><creator>Moron, Antonio Fernandes</creator><creator>Diniz, Angélica Lemos Debs</creator><creator>Nardozza, Luciano Marcondes Machado</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study</title><author>Melo, Nayana Alves De Brito ; Araujo Júnior, Edward ; Helfer, Talita Micheletti ; Caetano, Ana Carolina Rabachini ; Zamarian, Ana Cristina Perez ; Moron, Antonio Fernandes ; Diniz, Angélica Lemos Debs ; Nardozza, Luciano Marcondes Machado</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4579-830844a9110c844938dccc3e9f2b8bff5e799366829a0f53c9539777200c05923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Doppler</topic><topic>Echocardiography, Doppler</topic><topic>Female</topic><topic>fetal growth restriction</topic><topic>Fetal Growth Retardation - diagnostic imaging</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>ophthalmic artery</topic><topic>Ophthalmic Artery - diagnostic imaging</topic><topic>Ophthalmic Artery - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>Prospective Studies</topic><topic>Ultrasonography, Prenatal</topic><topic>uterine artery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melo, Nayana Alves De Brito</creatorcontrib><creatorcontrib>Araujo Júnior, Edward</creatorcontrib><creatorcontrib>Helfer, Talita Micheletti</creatorcontrib><creatorcontrib>Caetano, Ana Carolina Rabachini</creatorcontrib><creatorcontrib>Zamarian, Ana Cristina Perez</creatorcontrib><creatorcontrib>Moron, Antonio Fernandes</creatorcontrib><creatorcontrib>Diniz, Angélica Lemos Debs</creatorcontrib><creatorcontrib>Nardozza, Luciano Marcondes Machado</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melo, Nayana Alves De Brito</au><au>Araujo Júnior, Edward</au><au>Helfer, Talita Micheletti</au><au>Caetano, Ana Carolina Rabachini</au><au>Zamarian, Ana Cristina Perez</au><au>Moron, Antonio Fernandes</au><au>Diniz, Angélica Lemos Debs</au><au>Nardozza, Luciano Marcondes Machado</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J. Obstet. Gynaecol. Res</addtitle><date>2015-09</date><risdate>2015</risdate><volume>41</volume><issue>9</issue><spage>1330</spage><epage>1336</epage><pages>1330-1336</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
The aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses.
Material and Methods
A prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal fetuses) between 32 and 40 weeks of gestation. FGR diagnosis was based on an estimated fetal weight below the 10th percentile of the Hadlock curve. Ophthalmic artery Doppler images were obtained with a linear transducer, with color Doppler examination of the region medial to the optic nerve. The following indices were obtained: pulsatility index, resistance index, peak systolic velocity, second peak velocity (P2), end diastolic velocity, and P2 / peak systolic velocity ratio. The Mann–Whitney U‐test and Student's t‐test were used to compare the groups with regard to quantitative variables, and the χ2‐test was used for categorical variables.
Results
Pulsatility index and resistance index were significantly lower in pregnant women with FGR than in those with normal fetuses, with P < 0.001 in both indices. P2 and end diastolic velocity were significantly higher in pregnant women with FGR than in those with normal fetuses (P = 0.002 and P = 0.004, respectively). The P2 / peak systolic velocity ratio was significantly higher in the FGR group than in the control group (P < 0.001). In FGR subgroups, with (17 fetuses) and without (43 fetuses) uterine artery Doppler abnormalities, no significant changes were observed between the groups.
Conclusion
In the third trimester of pregnancy, we observed significant differences in the ophthalmic artery Doppler parameters of pregnant women with FGR compared with those with normal fetuses.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26044926</pmid><doi>10.1111/jog.12739</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2015-09, Vol.41 (9), p.1330-1336 |
| issn | 1341-8076 1447-0756 |
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| source | Wiley |
| subjects | Adult Case-Control Studies Cross-Sectional Studies Doppler Echocardiography, Doppler Female fetal growth restriction Fetal Growth Retardation - diagnostic imaging Fetal Growth Retardation - physiopathology Gestational Age Humans ophthalmic artery Ophthalmic Artery - diagnostic imaging Ophthalmic Artery - physiopathology Pregnancy Pregnancy Trimester, Third Prospective Studies Ultrasonography, Prenatal uterine artery Young Adult |
| title | Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case-control study |
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