Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer

Micro-Abstract Circulating tumor cells (CTCs) have shown prognostic importance in men with metastatic castration–resistant prostate cancer. Little information exists as to the yield of CTCs in men presenting with biochemical recurrence. This study sought to determine whether CTCs are detectable in s...

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Bibliographic Details
Published in:Clinical genitourinary cancer 2015-10, Vol.13 (5), p.e341-e345
Main Authors: Aragon-Ching, Jeanny B, Siegel, Robert S, Frazier, Harold, Andrawis, Ramez, Hendricks, Frederick, Phillips, Michael, Jarrett, Thomas, Guebre-Xabiher, Hiwot, Patierno, Steven, Simmens, Samuel J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biochemical recurrence
Biomarkers, Tumor - blood
Circulating tumor cells
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplastic Cells, Circulating - pathology
Prognosis
Prostate cancer
Prostate specific antigen
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms - surgery
PSA doubling times
Urology
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Summary:Micro-Abstract Circulating tumor cells (CTCs) have shown prognostic importance in men with metastatic castration–resistant prostate cancer. Little information exists as to the yield of CTCs in men presenting with biochemical recurrence. This study sought to determine whether CTCs are detectable in such men and whether it correlates with known clinicopathologic parameters. Although the overall yield was low (8%), finding a detectable CTC raises a suspicion for metastatic disease in our series.
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2015.04.003