Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese

Background The 2013 American College of Cardiology and the American Heart Association guidelines recommended the Pooled Cohort equations for evaluation of cardiovascular (CV) risk of individuals. Objective We investigated the usefulness of the Pooled Cohort equations in Chinese by validating this ri...

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Published in:Journal of clinical lipidology 2015-09, Vol.9 (5), p.640-646.e2
Main Authors: Lee, Chi Ho, MBBS, Woo, Yu Cho, MBChB, Lam, Joanne K.Y., MBBS, Fong, Carol H.Y., MSc, Cheung, Bernard M.Y., PhD, Lam, Karen S.L., MD, Tan, Kathryn C.B., MD
Format: Article
Language:English
Subjects:
Adult
Aged
American Heart Association
Asian Continental Ancestry Group - statistics & numerical data
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cholesterol
Cohort Studies
Female
Hong Kong - epidemiology
Humans
Male
Middle Aged
Models, Statistical
Primary prevention
Risk Assessment
Risk Factors
Statins
United States
Validation studies
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Summary:Background The 2013 American College of Cardiology and the American Heart Association guidelines recommended the Pooled Cohort equations for evaluation of cardiovascular (CV) risk of individuals. Objective We investigated the usefulness of the Pooled Cohort equations in Chinese by validating this risk prediction model using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort. Methods The Hong Kong CRISPS is a population-based prospective cohort study of CV risk factors among 2895 Chinese men and women (aged 25–74 years) initiated in 1995. CV events were ascertained until December 2012. The discrimination and calibration of the Pooled Cohort equations were evaluated and compared with the Framingham CV risk equation. A Hosmer–Lemeshow chi-square statistic (X2 ) of
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2015.06.005