Biological rhythms in bipolar and depressive disorders: A community study with drug-naïve young adults

• Published in: Journal of affective disorders 2015-11, Vol.186, p.145-148
• Main Authors: Duarte Faria, Augusto, Cardoso, Taiane de Azevedo, Campos Mondin, Thaise, Souza, Luciano Dias de Mattos, Magalhaes, Pedro Vieira da Silva, Patrick Zeni, Cristian, Silva, Ricardo Azevedo da, Kapczinski, Flavio, Jansen, Karen
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological rhythm; Bipolar disorder; Bipolar Disorder - complications; Case-Control Studies; Chronobiology Disorders - diagnosis; Chronobiology Disorders - etiology; Community sample; Cross-Sectional Studies; Depressive Disorder - complications; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Major depressive disorder; Male; Mood disorders; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychiatry; Reference Values; Sleep Disorders, Circadian Rhythm - etiology; Young Adult; Young adults
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2015.07.004

Abstract Aim To assess biological rhythm disruptions among drug-naïve young adults with bipolar disorder (BD), major depressive disorder (MDD), and community controls. Methods This was a cross-sectional study nested in a population-based study. BD and MDD were diagnosed using the Structured Clinical Interview for DSM-IV. Biological rhythm disruptions were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). Results Two hundred seventeen subjects were assessed (49 BD, 74 MDD, and 94 community controls). Biological rhythm disruption was higher in subjects with BD (40.32±9.92; p