Antiepileptic effect of low-frequency electrical stimulation is waveform-dependent in hippocampal kindled mice

To investigate whether the waveform of electrical stimulus affects the antiepileptic effect of focal low-frequency stimulation (LFS). The antiepileptic effects of the LFS in sine, monophase square and biphase square waves were investigated in hippocampal kindled mice, respectively. Compared to the c...

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Bibliographic Details
Published in:Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2015-05, Vol.44 (3), p.315-322
Main Authors: Tao, An-feng, Xu, Zheng-hao, Wu, Cheng-hao, Wang, Yi, Hou, Wei-wei, Zhang, Shi-hong, Chen, Zhong
Format: Article
Language:Chinese
Subjects:
Animals
Anticonvulsants
Electric Stimulation
Epilepsy
Hippocampus - physiopathology
Kindling, Neurologic
Mice
Seizures - physiopathology
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Summary:To investigate whether the waveform of electrical stimulus affects the antiepileptic effect of focal low-frequency stimulation (LFS). The antiepileptic effects of the LFS in sine, monophase square and biphase square waves were investigated in hippocampal kindled mice, respectively. Compared to the control group, sine wave focal LFS (30 s) inhibited seizure stages (2.85 ± 0.27 vs 4.75 ± 0.12, P
ISSN:1008-9292