The use of photodynamic therapy as adjuvant therapy to surgery in recurrent malignant tumors of the paranasal sinuses

Highlights • There is a need for additional treatment modalities in recurrent paranasal sinus cancers. • We have employed PDT as an adjuvant to surgery and assessed its feasibility. • PDT can be a valuable tool but safety needs to be assessed in the vicinity of important structures. • PDT is a feasi...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2015-09, Vol.12 (3), p.414-421
Main Authors: Caesar, L, van Doeveren, T.E.M, Tan, I.B, Dilci, A, van Veen, R.L.P, Karakullukcu, B
Format: Article
Language:English
Subjects:
Adult
Aged
Combined Modality Therapy
Endoscopic sinus surgery
Female
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Male
Mesoporphyrins - therapeutic use
Middle Aged
mTHPC (m-tetrahydroxyphenylchlorin)
Nasal cavity cancer
Neoplasm Recurrence, Local
Nose Neoplasms - drug therapy
Nose Neoplasms - pathology
Nose Neoplasms - radiotherapy
Nose Neoplasms - surgery
Paranasal sinus cancer
Paranasal Sinuses - pathology
Photochemotherapy - adverse effects
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Skull - pathology
Temoporfin
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Summary:Highlights • There is a need for additional treatment modalities in recurrent paranasal sinus cancers. • We have employed PDT as an adjuvant to surgery and assessed its feasibility. • PDT can be a valuable tool but safety needs to be assessed in the vicinity of important structures. • PDT is a feasible tool to use in the paranasal sinus and anterior skull base area. • Clinical efficacy of PDT in paranasal sinus area needs further experience.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2015.06.001