Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)

Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2015-09, Vol.12 (3), p.504-510
Main Authors: Guo, Han-Wen, Lin, Liang-Ting, Chen, Po-Hsiung, Ho, Meng-Huan, Huang, Wan-Ting, Lee, Yi-Jang, Chiou, Shih-Hwa, Hsieh, Yei-San, Dong, Chen-Yuan, Wang, Hsing-Wen
Format: Article
Language:English
Subjects:
5-Aminolevulinic acid (ALA)
Aminolevulinic Acid - pharmacology
Animals
Disease Models, Animal
Glioblastoma - drug therapy
Gliomas
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Metronomic photodynamic therapy (mPDT)
Mice
Mice, Nude
Organic light emitting diode (OLED)
Photochemotherapy - methods
Photosensitizing Agents - pharmacology
Pilot Projects
Protoporphyrins
Survival Analysis
Time Factors
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Summary:Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer fluorescence and oxygenation is critical for PDT.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2015.04.007