Impact of diabetes on fibrinogen levels and its relationship with platelet reactivity and coronary artery disease: A single-centre study

Highlights • Contrasting data have been reported on the relationship between fibrinogen and coronary disease. • Enhanced pro-thrombotic status is observed in diabetics, conditioning cardiovascular risk. • We evaluated the impact of diabetes on fibrinogen levels and CAD in 3280 patients. • Neither di...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-09, Vol.109 (3), p.541-550
Main Authors: Di Giovine, Gabriella, Verdoia, Monica, Barbieri, Lucia, Schaffer, Alon, Aimaretti, Gianluca, Bellomo, Giorgio, Marino, Paolo, Suryapranata, Harry, Sinigaglia, Fabiola, De Luca, Giuseppe
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Blood Glucose - metabolism
Blood Platelets - physiology
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - diagnostic imaging
Diabetes Mellitus - epidemiology
Diabetic Angiopathies - blood
Diabetic Angiopathies - diagnostic imaging
Diabetic Angiopathies - epidemiology
Endocrinology & Metabolism
Female
Fibrinogen
Fibrinogen - analysis
Humans
Male
Middle Aged
Platelet Aggregation
Prevalence
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Summary:Highlights • Contrasting data have been reported on the relationship between fibrinogen and coronary disease. • Enhanced pro-thrombotic status is observed in diabetics, conditioning cardiovascular risk. • We evaluated the impact of diabetes on fibrinogen levels and CAD in 3280 patients. • Neither diabetes nor glucose homeostasis parameters resulted as independent predictors of hyperfibrinogenemia. • Among diabetics, fibrinogen elevation did not affect platelet reactivity nor the prevalence of CAD.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.05.038