Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma

Highlights • A total of 998 DEGs and 160 differentially expressed lncRNAs were screened out • FTH1P3, PDIA3F and GTF2IRD2P1 targeted most of DEGs in co-expression network • Up-regulated candidate targets were mainly involved in inflammation-related functions • Up-regulated target genes were signific...

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Bibliographic Details
Published in:Archives of oral biology 2015-10, Vol.60 (10), p.1581-1587
Main Authors: Zhang, Shanchuan, MD, Tian, Lili, MD, Ma, Penghua, MD, Sun, Qiang, MD, Zhang, Kai, MD, GuanchaoWang, MD, Liu, Hongchen, MD, Xu, Baohua, MD
Format: Article
Language:English
Subjects:
Advanced Basic Science
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
co-expression network
Computational Biology
Dentistry
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - metabolism
Humans
Interleukin-8
long non-coding RNA
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Oligonucleotide Array Sequence Analysis
oral squamous cell carcinoma
RNA, Long Noncoding - biosynthesis
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
Squamous Cell Carcinoma of Head and Neck
Up-Regulation
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Summary:Highlights • A total of 998 DEGs and 160 differentially expressed lncRNAs were screened out • FTH1P3, PDIA3F and GTF2IRD2P1 targeted most of DEGs in co-expression network • Up-regulated candidate targets were mainly involved in inflammation-related functions • Up-regulated target genes were significantly enriched in Toll-like receptor pathway.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.08.003