Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility

Abstract Spermatogenesis is a complex process of proliferation and differentiation during male germ cell development involving mitosis, meiosis and spermiogenesis. Endogenous and exogenous physical, chemical and biological sources modify the genome of spermatozoa. The genomic integrity and stability...

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Bibliographic Details
Published in:Reproductive biomedicine online 2015-09, Vol.31 (3), p.309-319
Main Authors: Gunes, Sezgin, Al-Sadaan, Maha, Agarwal, Ashok
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - physiology
DNA Damage
DNA Repair
DNA repair mechanisms
Humans
infertility
Infertility, Male - genetics
Infertility, Male - physiopathology
Male
Obstetrics and Gynecology
spermatogenesis
Spermatogenesis - physiology
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Summary:Abstract Spermatogenesis is a complex process of proliferation and differentiation during male germ cell development involving mitosis, meiosis and spermiogenesis. Endogenous and exogenous physical, chemical and biological sources modify the genome of spermatozoa. The genomic integrity and stability of the sperm is protected by DNA repair mechanisms. In the male germline cells, DNA repair mechanisms include nucleotide excision repair, base excision repair, DNA mismatch repair, double strand break repair and post-replication repair. Defects in repair mechanisms cause arrest of spermatogenesis and abnormal recombination, ultimately resulting in male infertility. This review focuses on molecular mechanisms of the DNA repair pathways, DNA repair defects and male infertility.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2015.06.010