Usefulness of Beta2-Microglobulin as a Predictor of All-Cause and Nonculprit Lesion-Related Cardiovascular Events in Acute Coronary Syndromes (from the PROSPECT Study)

In the Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) study, plaque burden, plaque composition, and minimal luminal area were associated with an increased risk of adverse cardiovascular events arising from untreated atherosclerotic lesions (vulnerable p...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2015-10, Vol.116 (7), p.1034-1040
Main Authors: Möckel, Martin, MD, Muller, Reinhold, PhD, Searle, Julia, MD, Slagman, Anna, MSc, De Bruyne, Bernard, MD, Serruys, Patrick, MD, Weisz, Giora, MD, Xu, Ke, PhD, Holert, Fabian, Müller, Christian, PhD, Maehara, Akiko, MD, Stone, Gregg W., MD
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - complications
Acute coronary syndromes
Aged
Angina pectoris
Atherosclerosis
beta 2-Microglobulin - blood
Biomarkers
Biomarkers - blood
Cardiovascular
Cardiovascular disease
Cause of Death - trends
Confidence intervals
Coronary vessels
Female
Follow-Up Studies
Global Health
Heart attacks
Humans
Incidence
Male
Medical imaging
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Peptides
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Factors
Shipments
Survival Rate - trends
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) study, plaque burden, plaque composition, and minimal luminal area were associated with an increased risk of adverse cardiovascular events arising from untreated atherosclerotic lesions (vulnerable plaques) in patients with acute coronary syndromes (ACS). We sought to evaluate the utility of biomarker profiling and clinical risk factors to predict 3-year all-cause and nonculprit lesion-related major adverse cardiac events (MACEs). Of 697 patients who underwent successful percutaneous coronary intervention (PCI) for ACS, an array of 28 baseline biomarkers was analyzed. Median follow-up was 3.4 years. Beta2-microglobulin displayed the strongest predictive power of all variables assessed for all-cause and nonculprit lesion-related MACE. In a classification and regression tree analysis, patients with beta2-microglobulin >1.92 mg/L had an estimated 28.7% 3-year incidence of all-cause MACE; C-peptide 1.92 mg/L identified a cohort with a 3-year rate of 18.5%, and C-peptide
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.07.017