Use of atropine in patients with recent myocardial infarction during exercise myocardial perfusion study

Background: Patients with recent myocardial infarction frequently require a myocardial perfusion study for risk stratification. However a conclusive study cannot be accomplished in many due to non-attainment of target heart rate. Aim of the study: To evaluate the effect of pre-stress administration...

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Bibliographic Details
Published in:International Journal of Cardiovascular Imaging 2005-08, Vol.21 (4), p.413-419
Main Authors: Barai, S, Patel, C. D, Malhotra, A, Bandopadhayaya, G. P, Gambhir, S, Kumar, R, Dhanapathi, H
Format: Article
Language:English
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Summary:Background: Patients with recent myocardial infarction frequently require a myocardial perfusion study for risk stratification. However a conclusive study cannot be accomplished in many due to non-attainment of target heart rate. Aim of the study: To evaluate the effect of pre-stress administration of atropine in exercise performance of patients with recent myocardial infarction. Material and methods: Study included 43 test and 43 control patients and were matched for their age, sex, status of pretest exercise tolerance, area of infarction and for interval between infarction and stress thallium test. Atropine (0.01 mg/kg) was administered intravenously 3 min prior to treadmill stress in all the 43 test patients and no atropine was administered to control patients. Results: Target heart rate was attained in 95.3% patients receiving atropine compared to in 67.4% of control patients. There was no significant difference between mean ages (p>0.33), basal BP (p>0.47), peak BP (p>0.18) of both groups. There was significant difference between the increment in exercise-induced heart rate (p
ISSN:1569-5794
1573-0743
DOI:10.1007/s10554-004-7984-0