Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

Purpose Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown. Methods Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized). Results Nicotine inhalation was associated with higher arterial pressures in the seat...

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Bibliographic Details
Published in:Clinical autonomic research 2015-08, Vol.25 (4), p.267-270
Main Authors: Cooke, William H., Pokhrel, Anusheela, Dowling, Colin, Fogt, Donovan L., Rickards, Caroline A.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Arterial Pressure - drug effects
Arterial Pressure - physiology
Cardiology
Diabetes
Electronic Nicotine Delivery Systems - adverse effects
Electronic Nicotine Delivery Systems - trends
Endocrinology
Female
Gastroenterology
Humans
Hypertension - chemically induced
Hypertension - diagnosis
Hypertension - physiopathology
Male
Medicine
Medicine & Public Health
Neurology
Nicotine - administration & dosage
Ophthalmology
Pilot Projects
Short Communication
Tilt-Table Test - methods
Volatilization
Young Adult
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Summary:Purpose Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown. Methods Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized). Results Nicotine inhalation was associated with higher arterial pressures in the seated position, and increased arterial pressures in the head-up positions with no other effects on autonomic control. Conclusions Our results show that vaporized nicotine inhalation is not innocuous. Longitudinal studies in otherwise healthy non-smokers should be conducted.
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-015-0304-z