Niche Applications of Irreversible Electroporation

Irreversible electroporation (IRE) induces cell death by exposing it to high-voltage, low-energy DC current pulses. The mechanism of cell death and healing is a departure from the other existing technologies such as radiofrequency ablation, microwave ablation, and cryoablation. These thermal ablativ...

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Bibliographic Details
Published in:Techniques in vascular and interventional radiology 2015-09, Vol.18 (3), p.170-175
Main Authors: Bhatia, Shivank S., MD, Arya, Rahul, MD, Narayanan, Govindarajan, MD
Format: Article
Language:English
Subjects:
ablation
Ablation Techniques - adverse effects
Ablation Techniques - instrumentation
Aged
Cell Death
Electroporation - instrumentation
Electroporation - methods
Equipment Design
Female
Hematology, Oncology and Palliative Medicine
Humans
irreversible electroporation
Male
Neoplasms - pathology
Neoplasms - surgery
niche application
pancreas
Positron-Emission Tomography
Postoperative Complications - etiology
Radiology
Risk Factors
Surgery, Computer-Assisted - adverse effects
Surgery, Computer-Assisted - instrumentation
Surgery, Computer-Assisted - methods
Tomography, X-Ray Computed
Treatment Outcome
vascular
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Summary:Irreversible electroporation (IRE) induces cell death by exposing it to high-voltage, low-energy DC current pulses. The mechanism of cell death and healing is a departure from the other existing technologies such as radiofrequency ablation, microwave ablation, and cryoablation. These thermal ablative technologies have several applications in oncology but have limitations that have also been established. IRE has shown promise to overcome some of these limitations and has enabled the use of an ablative technology in treating lesions close to the bile ducts and vasculature and in organs such as the pancreas. This review highlights some of the niche applications of IRE and the data so far.
ISSN:1089-2516
1557-9808
DOI:10.1053/j.tvir.2015.06.008